Premature Ejaculation - New Treatments

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Topical Anesthetic Spray Could Offer Exciting and Effective Treatment For Men Who Experience Premature Ejaculation

The new treatment is a spray which men apply to the glans of their penis before intercourse. Of course we have seen anesthetic as a treatment for premature ejaculation before, in condoms with an anesthetic lotion. But these do not seem to have been particularly successful. The new medication developed and tested by the researchers is called the TEMPE spray (which stands for Topical Eutectic Mixture for Premature Ejaculation); it offers a combination of lidocaine and prilocaine which can be applied by spray to the glans of the penis. According to initial reports from men with premature ejaculation, the average increase in the length of intercourse in men using the product is just over four minutes. (Professor Wallace Dinsmore who is located at the Royal Victoria Hospital, in Northern Ireland, Belfast.)

In the same study, the placebo or control group, who were given a spray which contained no active chemicals, managed to extend intercourse by just over forty five seconds.

The study was conducted on heterosexual couples who had been in a stable one to one relationship for at least three months and who were prepared to try having sexual intercourse seven or more times during the ten-week period over which the study was conducted. This research on the new treatment for premature ejaculation was carried out in seven medical centers in Sheffield, Manchester, Durham, Plymouth, Belfast, London and The Hague on men with an age range of 18 to 75, and an average age of 39. These men had been having premature or rapid ejaculations for a period of between seven months and over thirty years; the average length of time was nine and a half years.

The men in the TEMPE group were instructed to apply three measured amounts of the medication by spray about a quarter of an hour before intercourse, a delivery which administered a total of 22.5mg of lidocaine and 7.5mg of prilocaine to the glans of their penis. The placebo group had a spray which contained no active ingredients. Both sets of men were told not to administer more than one application in any twenty four hour period. This was an attempt to stop the men affecting their own latency time by having more than one ejaculation in any twenty four hour period. (Though it may have been simpler and possibly more accurate to simply tell the men not to have more than one ejaculation in a day. This would have ruled out the possibility that they would masturbate to orgasm. The instruction not to use the spray seems to imply the researchers equated ejaculations with intercourse.)

To get some sense of the increase in time between penetration and ejaculation, the men were given a stopwatch so that they could measure the duration of intercourse. (Alternatively their partners could record the time lapse.) 

Initial results were promising and encouraging for men who have premature ejaculation. Twenty TEMPE users and roughly the same number of control group men completed the study; about four fifths of all the men said that the premature ejaculation spray was easy to use. Since one of the complaints about anesthetic creams or lotions designed to combat premature ejaculation and applied to the penis has always been that they can numb the vagina of the partner of the man using them, it seems a little surprising that most of the men in the study - and apparently their partners - seemed to have no problems using the spray. Nonetheless, the vast majority of the TEMPE users and their partners said that they tolerated the spray well. The only adverse effects reported were numbness in the penis (three men), the inability to get an erection (one man) and a report form one man's partner of a mild burning sensation each time the couple used the spray. This latter couple continued with the treatment. A series of medical checks were conducted on the men and these found no adverse medical effects in the areas of vital signs, urine analysis, electrocardiograms, hematology and biochemistry.

Dr Michael Wyllie from Plethora Solutions has observed that only a small number of men with premature ejaculation seek help. One of the reasons for this may be the lack of a simple drug treatment - therapy and counseling is not with the reach of all men - so the application of a topical spray which is well-tolerated, effective, and lacks side-effects is a promising step forward. He goes on to say that since all the above criteria are fulfilled, TEMPE may offer a convenient, new treatment for men who have premature ejaculation; it may even be an effective first-line treatment for the condition.

For more information, see: Topical eutectic mixture for premature ejaculation: an aerosol-delivery form of prilocaine-lidocaine for use in treating premature ejaculation. Dinsmore et al. BJU International. Volume 99, pages 369-375. (February 2007).

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