Background to premature
ejaculation
Premature ejaculation (PE) is without doubt the most common
sexual problem in men under 40 years of age. Most doctors who
work with men complaining of early ejaculation define PE as an ejaculation
within a certain timescale (say two minutes) which also happens before
both sexual partners wish it to do so. The problem with defining PE is
that it is only a problem - and therefore only really exists as a
condition within a relationship - if both partners are unhappy about it.
Many couples live with rapid ejaculation and build their other sexual
activities around it (e.g. by giving the woman an orgasm before sexual
intercourse through masturbation or cunnilingus). If a rapid ejaculation
happens more than fifty percent of the time a couple engage in sexual
intercourse, then treatment may be appropriate.
Of course, as has been repeatedly stated on this
and many other websites, many women do not reach orgasm through
intercourse, so it is possible that this definition is inadequate. For
example, when a man is actually able to last for twenty minutes during
sex before he ejaculates, but his partner requires thirty minutes of
thrusting during intercourse before she can reach orgasm by vaginal
stimulation, it is questionable whether the man is suffering from
premature ejaculation! (Indeed, few experts would call this premature
ejaculation!)
Male and female sexual response has at least 3
phases: sexual desire (libido), sexual excitement (arousal), and orgasm.
Premature ejaculation may be defined as primary or secondary
PE.
Primary PE is a category for men who have had t as a lifelong experience
during sex. Secondary PE suggests a man once had acceptable ejaculatory control,
but now, for some reason, has begun to experience premature ejaculation
later in life. Although much work has gone into the condition, no one
really knows why some men ejaculate faster than others - indeed, it
could be that fast ejaculation is actually normal. But a psychological
cause is most likely...
Pathophysiology of
Premature Ejaculation
Premature ejaculation as a
psychological problem does not involve any known disease
of the male reproductive tract or any so far discovered problems of the brain
or nervous system. Could the problem lie somewhere in the male reproductive
system (i.e., penis, prostate,
seminal vesicles, testicles)? The answer is that we do not really know.
But when PE happens before satisfying intercourse is completed, both the
man and his partner will be dissatisfied
both emotionally and physically.
Premature ejaculation has often been spoken of as
a psychological problem. As you may have seen, some experts have
suggested that young men are
conditioned by societal pressures to ejaculate in rapid order because of
fear of discovery when masturbating or during early sexual experiences.
But although this may become a habit, it's hard to imagine it is
actually an ingrained physiological response which cannot be changed
later in life. Therefore, some researchers have suggested there may be a
physical cause, such as
differences in nerve conduction rates or hormonal differences
between men: even hyper-excitability or
oversensitivity of the penile nerves has been suggested. This would stop down-regulation of
their sympathetic nervous system pathways and inhibit delay of orgasm.
In some cases premature ejaculation represents
other issues: e.g. a cardiac patient may fear a myocardial infarction
during sex, and so develop premature ejaculation.
But it is logical from an
evolutionary point of view that males who ejaculated rapidly would have
more success when mating and fertilizing a female than those who needed
prolonged mating time. Therefore, the genes of a male who came quickly would
stand more chance of passing his genes on to the next generation - and
also, a male who took a long time to mate might well be killed because of his vulnerability during
intercourse.
Frequency of premature
ejaculation
Premature ejaculation occurs in between 30 and 70%
of men. The percentage is similar in all age categories: of course, erectile
dysfunction becomes more common in older age groups. Since many men do not
discuss rapid or premature ejaculation with their doctor, probably
because of embarrassment or
a sense of hopelessness around a cure, or even because they are
satisfied with the quality of their ejaculations (no matter how quickly
they occur), the proportion of men who have premature ejaculation in
their lives is almost certain to exceed conventionally accepted figures
of 30%.
Race and premature
ejaculation
No firm data exists on the subject.
Age and premature
ejaculation
Premature ejaculation is most common
in younger men (in an age group between 18 and 30 years) but is far from
uncommon in men aged 45-65 years, where it is often associated with
erectile dysfunction.
Treating Premature Ejaculation
Treatment will vary according to whether
premature ejaculation has been a lifelong problem (i.e., primary) or has
been acquired later in life (i.e.,
secondary).
Primary premature ejaculation - factors
associated with early ejaculation
- Prior psychological difficulties: there is
some evidence men with prior psychiatric conditions have higher
rates of PE than other men
- Traumatic sexual episodes during childhood or
adolescence - even discovery by mother or father masturbating can
produce inhibiting guilt: shame and punishment for masturbation is
also a cause of inhibited sexual responses during adulthood
- Family incest or sexual assault, sexual
assaulted by either family members or non-family members
- Difficulties with work, socializing, studies
- General attitude toward
sex (for example, is it seen as shameful or dirty)
- Abnormal or guilt inducing sexual
preferences, fantasy life, and sexual arousal patterns
- Strict religious upbringing with negative
teachings about sex
- Guilt about sexual relationships
- A pattern of early ejaculation even before
sexual intercourse began
- Problems with the sexual attitudes and sexual
responses of the female partner
- Relationship dynamics: are the couple
harmonious or do they fight a lot?
- Blame or lack of support from the female
partner
Secondary premature ejaculation -
factors of relevance
- Has PE been a problem in previous
relationships?
- In the current relationship, is early
ejaculation a long-standing problem or has it started recently?
- Is conflict between the two partners present?
Who is dominant: is the relationship generally equal in the balance
of power, both sexual and non-sexual?
- Is the female partner supportive?
- Does the man have a problem with erectile dysfunction (ED),
and if so, what is its relationship to the rapid ejaculation?
- Can intercourse be completed satisfactorily?
- Does premature
ejaculation occur during other forms of sex play?
- Does the female partner reach orgasm during
intercourse, or does she require direct clitoral stimulation to
reach climax?
- If ED began after the
premature ejaculation, then both need treating; if the ED came
first, the premature ejaculation may be a secondary sexual
dysfunction, which resolves spontaneously when the man has regained
his erectile power.
Causes of
premature ejaculation
The cause of premature ejaculation is considered
psychological, although no one really knows.
Primary premature ejaculation
- Deep-seated emotional disturbance may be
causing PE
- Deep anxiety about sex due to traumatic
experiences including family incest, sexual assault, conflict with
one or both parents, or other psychological disturbances.
Secondary premature ejaculation
- Performance anxiety is often a major factor.
- Performance pressure - such as fear of not
being able to satisfy the partner - can be caused by many things,
including ED.
- Previous ED or imagined erectile failure may
precipitate premature ejaculation.
- Comments such as "You aren't much of a man,
you can't stay hard or satisfy me" may reduce his sexual
self-confidence.
- If the woman can't come through sexual
intercourse, and doesn't tell her partner, he may feel like a failure
- which in some sense he will be since he seeks to do the impossible.
Other Problems to be Considered
Women may have anorgasmia or severely delayed
orgasm. Delayed or
difficult orgasm in the female partner may define the man's premature
ejaculation.
Drug usage and premature ejaculation are often
linked.
Lubricating fluids produced by Cowper's glands may
be taken as ejaculate by te sexually naive.
Erectile dysfunction (ED) can be a
symptom in men who are actually experiencing premature ejaculation.
In men with premature ejaculation
- checks of serum testosterone (free and total)
and prolactin levels may reveal some underlying hormonal issue if
premature ejaculation and impotence are both present
- depression may cause impotence or premature
ejaculation
- vibrational threshold testing is considered
experimental
- including the female partner in the treatment
and counseling helps
- the first step is to relieve any performance
pressure on the man
Treatment of premature ejaculation
Intercourse should stop until premature ejaculation
is treated. The man can use masturbation or oral stimulation to satisfy
his partner.
One approach is to use the stop-start or squeeze-pause technique popularized
by Masters and Johnson.
The woman slowly masturbates her partner but stops
as soon as he senses ejaculatory
inevitability.
Then, she should firmly squeezes his penis just
under his glans - uncomfortable but not painful. Masturbation stimulation should begin
once more when the man loses the feeling that his ejaculation is imminent.
The process is repeated / practiced
for ten cycles or more.
Most men find a gradual improvement
in ejaculatory control.
After a period, the
couple sit facing each other, positioned so the female partner's legs cross on
top of her partner's. She can arouse him by rubbing his penis
against her vulval area. As before, when he approaches ejaculation, she can squeeze and
stop all stimulation, then repeat the process.
Finally, intercourse may be attempted, with the
woman on top so that she can withdraw his penis if he approaches
ejaculation and apply a squeeze to reduce his urge to ejaculate.
Most couples find this technique
successful. It can also shorten her time to orgasm since it is a
form of extended foreplay.Another therapy
- desensitizing cream for the man
SS Cream (a combination of 9
ingredients, mainly herbal) desensitizes the penis and helps men with
premature ejaculation to delay their ejaculation.
SS Cream is not approved by the US
Food and Drug Administration (FDA), but a similar principle applies to
lidocaine cream or other topical anesthetic agents; they are safe as
long as the man has no allergy to the active ingredient,
If the man is relatively young, he
may find that his ejaculatory control is much better if he attempts
intercourse a second time soon after his arousal has dropped.
It may be helpful to
masturbate to orgasm
1-2 hours before sex is planned. The interval for achieving a second
ejaculation is much longer, and a man can usually exert better control.
This is not so effective for an older man, because of problems in
getting a second erection.
The most effective drug to help with premature ejaculation is a selective
serotonin reuptake inhibitors (SSRIs) or a tricyclic antidepressants with SSRI-like
activity. These drugs have a side effect of a tendency to delay reaching orgasm.
Medications with SSRI side
effects have therefore been offered to men with premature ejaculation.
There is, however, no drug is approved by the FDA for treatment
of rapid ejaculation.
Some studies have shown that
selective serotonin reuptake inhibitors (SSRIs) and drugs with SSRI-like
side effects can be effective in treating PE. SSRIs have been the most
effective in delaying too-rapid ejaculation.
Premature ejaculation associated with erectile
dysfunction (ED) may resolve if the ED is treated successfully with sildenafil (Viagra), vardenafil (Levitra),
tadalafil (Cialis), or even the older drug alprostadil (Caverject, Muse).
If a man has depression-related ED only, the use of an antidepressant drug with
few or no sexual effects might be used to avoid creating delayed
ejaculation or even anorgasmia. These would include bupropion HCl
(Wellbutrin) or venlafaxine HCL (Effexor). Needless to say, if a man has premature
ejaculation, rectile problems, and depression, an antidepressant
with SSRI side effects may help solve the premature ejaculation issue.
Drug Category: Selective serotonin reuptake
inhibitors
Their action is linked to reducing uptake of
serotonin in the central nervous system. SSRIs have weak effects on norepinephrine
and dopamine neuronal reuptake. They do not antagonize adrenergic, cholinergic, GABA, dopaminergic, histaminergic, serotonergic,
or benzodiazepine receptors; this means they have fewer adverse anticholinergic effects than
the family of tricyclic antidepressants.
SSRIs cause sexual side
effects, including delay in sexual orgasm for both men and women; while delayed
in reaching orgasm caused by an SSRI is
an adverse effect in women, the same may not be true in men. Indeed, it
can help to overcome too-rapid orgasm. Sertraline (Zoloft), paroxetine
(Paxil), and fluoxetine (Prozac) are helpful SSRIs for treating premature
ejaculation.
The optimal treatment for premature
ejaculation is unknown, but
single dosing before sex works for some men, while daily use of the
medication may be necessary for others. The daily dose may be increased
gradually until a therapeutic effect is achieved. If one SSRI doesn't
help, using a
second alternative is reasonable. After 6 weeks at maximal dose with no improvement,
no further treatment is recommended.
|
Drug Name |
Sertraline
(Zoloft) |
|
Description |
Potent SSRI
used to treat premature ejaculation. Improvement may not be evident
until at least 3 wk following initiation of treatment. If no benefit
with respect to premature ejaculation after 6 weeks or if adverse
effects become troublesome, discontinue in favor of alternative
treatment. |
|
Adult Dose |
50 mg PO
2-12 h before sexual relations; alternatively, 50 mg/d PO; gradually
titrate to response; not to exceed 200 mg/d |
|
Contraindications |
Documented
hypersensitivity; concomitant MAOIs or use within 14 days |
|
Interactions |
Increases
toxicity of MAOIs, diazepam, tolbutamide, and warfarin; additive CNS
effects with alcohol, antidepressants, opioid analgesics, sedatives,
and hypnotics; suspension contains alcohol and, therefore, is
contraindicated in patients taking disulfiram (Antabuse) |
|
Precautions |
Caution in
recent MI or unstable heart disease; hyponatremia; although minimal
adverse anticholinergic effects (compared with TCAs), use with
caution in glaucoma, bladder outlet obstruction, chronic
constipation, and other conditions in which adverse anticholinergic
effects may exacerbate symptoms; caution in patients with
moderate-to-severe renal or hepatic impairment, because of excessive
blood level accumulation, adjust dose accordingly; does not impair
motor or cognitive ability with respect to performance of complex
tasks, nor does it cause somnolence, but any drug affecting the CNS
may cause drowsiness, and driving and performance of other tasks
requiring alertness and concentration should be avoided; seizures
are rare, use with caution in preexisting seizure disorder; when
used for premature ejaculation (off-label), patients with clinical
depression should be treated by a mental health care professional,
potential for depressed patients to commit suicide; priapism has
been (rarely) reported |
| Drug Name |
Paroxetine
(Paxil) |
| Description |
Potent SSRI
antidepressant used to treat premature ejaculation. Improvement may
not be evident until at least 3 wk following initiation of
treatment. If no benefit (with respect to premature ejaculation)
after 6 wk or adverse effects become troublesome, medication should
be discontinued in favor of an alternative treatment. |
| Adult Dose |
20 mg PO
2-12 h before sexual relations; alternatively, 20 mg/d PO, gradually
titrate to response; not to exceed 40 mg/d |
|
Contraindications |
Documented
hypersensitivity; concomitant MAOIs or use within 14 d |
| Interactions |
Phenobarbital and phenytoin decrease effects; alcohol, cimetidine,
sertraline, phenothiazines, and warfarin increase toxicity; additive
CNS depressant effects with other antidepressants, opioid
analgesics, sedatives, and hypnotics; increases toxicity of MAOIs |
| Precautions |
Caution in
recent MI or unstable heart disease; hyponatremia; although minimal
adverse anticholinergic effects (compared with TCAs), use with
caution in glaucoma, bladder outlet obstruction, chronic
constipation, and other conditions in which adverse anticholinergic
effects may exacerbate symptoms; also caution in moderate-to-severe
renal or hepatic impairment, because of excessive blood level
accumulation (adjust dose accordingly); does not impair motor or
cognitive ability with respect to performance of complex tasks, nor
does it cause somnolence, but any drug affecting the CNS may cause
drowsiness, and driving and performance of other tasks requiring
alertness and concentration should be avoided; seizures are rare;
caution in preexisting seizure disorder; when used for premature
ejaculation (off-label), patients with clinical depression should be
treated by a mental health care professional; potential for
depressed patients to commit suicide; priapism has been (rarely)
reported |
| Drug Name |
Fluoxetine
(Prozac) |
| Description |
Potent SSRI
used to treat premature ejaculation. Improvement may not be evident
until at least 3 wk following initiation of treatment. If no benefit
with respect to premature ejaculation after 6 wk or if adverse
effects become troublesome, discontinue in favor of alternative
treatment. |
| Adult Dose |
5-60 mg/d
PO; most clinicians begin at 10-20 mg/d (in one dose or in two
divided doses), or taken 2 h prior to intercourse as single-dose
therapy; total daily dose not to exceed 80 mg/d |
|
Contraindications |
Documented
hypersensitivity; concomitant MAOIs or use within 14 d; thioridazine
within 5 wk of discontinuation |
| Interactions |
Phenobarbital and phenytoin decrease effects; alcohol, cimetidine,
sertraline, phenothiazines, and warfarin increase toxicity; additive
CNS depressant effects with other antidepressants, opioid
analgesics, sedatives, and hypnotics; increases toxicity of MAOIs;
can alter levels of antidiabetic drugs (they may need adjustment);
can alter levels of warfarin, digitalis, or both; may increase
benzodiazepine, phenytoin, and carbamazepine levels; increased
adverse effects with tryptophan; lithium levels can increase or
decrease and need monitoring; may potentiate drugs metabolized by
CYP2D6, antipsychotics (eg, haloperidol, clozapine), or other
antidepressants; avoid alcohol, during or within 14 d of MAOIs, or
within 5 wk of thioridazine discontinuation; caution with drugs that
impair hemostasis (eg, nonselective NSAIDS, aspirin, warfarin)
because of increased risk of bleeding |
| Precautions |
Discontinue
upon unexplained allergic reaction; monitor for symptoms of mania or
hypomania; caution with diseases or conditions that could affect
metabolism or hemodynamic responses, diabetes, history of seizures,
suicidal tendencies; altered platelet function and hyponatremia
reported; monitor for clinical worsening or suicidality, especially
at initiation of therapy or dose changes; avoid abrupt withdrawal;
monitor for discontinuation symptoms |
Drug Category: Topical anesthetic agents
Topical anesthetic agents reduce penile
sensitivity and delay ejaculation, and are probably the lowest-risk
medication for premature ejaculation, having no adverse systemic
effects. they may be used with antidepressants, and behavioral therapy.
| Drug Name |
Lidocaine
2.5% and prilocaine 2.5% (EMLA) |
| Description |
Applied to
intact skin under an occlusive dressing, provides dermal analgesia.
Effectiveness of this when applied to the penis is not proven; an
occlusive dressing might also be difficult unless the penis is
covered with a condom or cellophane. Lidocaine and prilocaine are
amide-type local anesthetic agents. Both lidocaine and prilocaine
stabilize neuronal membranes by inhibiting the flow of certain ions
required for the initiation and conduction of nerve impulses, thus
producing local anesthesia. |
| Adult Dose |
Apply
liberally to entire penile skin 1-2 h before sexual intercourse;
effect may last up to 1 h or longer after occlusive dressing or
condom is removed. Consider removal of any remaining excess
medication from penis prior to intercourse to avoid reduction in
partner's vaginal sensitivity. |
|
Contraindications |
Documented
hypersensitivity in patient or partner |
| Interactions |
None
reported |
| Precautions |
Cautious
application to skin with rash, skin eruption, or other skin
irritation |
Drug Category: Phosphodiesterase type 5
inhibitor (PDE5 inhibitor)
Studies have shown that Viagra and other PDE5 inhibitors
work better is topping PE when combined with SSRIs. We don't know why,
but it may be that an improved erection from the PDE5 inhibitor causes inhibition of ejaculation via
down-regulation of receptors involved in somatosensory latency times.
More likely, a lower level of performance anxiety causes greater sexual
self-confidence. PDE5 inhibitors are safe
and effective as part of a treatment regime for premature ejaculation
where there is no other contraindication.
| Drug Name |
Sildenafil
(Viagra) |
| Description |
Sildenafil
is FDA-approved for the treatment of erectile dysfunction (ED) but
not specifically for premature ejaculation. If both conditions are
present, sildenafil may help both problems based on recent studies.
Sildenafil in combination with SSRI-type drugs helps premature
ejaculation better than SSRI-type medication alone, as measured by
prolongation of intravaginal ejaculatory latency time (IELT). More
drug-related adverse events may occur because 2 medications are
being used (sildenafil and an SSRI) rather than just one. |
| Adult Dose |
Starting
dose can range from 25-50 mg PO 1-2 h prior to sexual intercourse;
best taken on empty stomach; maximum dose is 100 mg |
|
Contraindications |
Use is
contraindicated in patients who are also taking organic nitrates
either intermittently or regularly |
| Interactions |
Increased
levels with CYP3A4 inhibitors (eg, cimetidine, ketoconazole,
itraconazole, erythromycin, saquinavir) and protease inhibitors (eg,
ritonavir); CYP2C9 inhibitors may decrease sildenafil clearance;
CYP3A4 inducers (eg, rifampin) may decrease levels; potentiates
hypotensive effects of nitrates; additional supine BP reduction with
amlodipine reported; simultaneous administration with alpha-blockers
may lead to symptomatic hypotension; sildenafil dose should not
exceed 25 mg and should not be taken within 4 h of taking an
alpha-blocker (tamsulosin HCL [Flomax] may be an exception, as it is
much more specific for prostate receptors than for vascular smooth
muscle receptors); avoid with other ED treatments (increased risk of
priapism) |
| Precautions |
Caution with
MI, stroke, or life-threatening arrhythmia within last 6 months;
with resting hypotension (BP < 90/50) or hypertension (BP >
170/110); unstable angina due to cardiac failure or CAD; anatomical
penile deformation; predisposition to priapism; and retinitis
pigmentosa; avoid in men where sexual activity is inadvisable due to
underlying cardiovascular status; decrease in supine BP reported |
Consultations
A sex therapist or psychotherapist may prove helpful
for men with
emotional disturbance that is an underlying cause or effect of
premature ejaculation.