Premature Ejaculation Treatment

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Latest developments for men who climax too rapidly.

Sciele Pharma Inc. announced in July 2009 that another double-blind, placebo-controlled study of their new compound PSD502, designed for for the treatment of rapid or premature ejaculation has fulfilled all the measures needed to regard it as a successful treatment. These measures include standards of Intravginal Ejaculatory Latency Time and the International Index of Sexual Satisfaction.

The latest study, whose precursor is reported elsewhere, was conducted on men from the USA, Canada and Europe. Previous research had been conducted on men from Europe, and the results reported in November 2008. Final approval for the product will be sought on the basis of the combined data.

The President and Chief Operating Officer of Sciele Pharma, Ed Schutter, reminded us that if the product gets FDA approval, it will be the first prescription treatment in the United States specifically designed to deal with the common condition of premature ejaculation.

The study was conducted as a multi-centre, double-blind, randomized, and, above all, placebo controlled investigation on 540 men with treatment for premature ejaculation offered for a 12-week period with the possibility of another voluntary phase of up to thirty sex weeks.

Both the first and second studies showed consistent results. PSD502 showed highly statistically significant improvements from the start of the study in all measures: intra-vaginal ejaculation latency time (IELT), ejaculatory control, sexual satisfaction, and partner satisfaction.

More specifically, IELT improved by a factor of six; the IPE domains for ejaculatory control and sexual satisfaction showed a five point increase; and partner satisfaction increased "considerably". All these results were highly statistically significant.

Happily, there were no more serious adverse events and overall side effects in the group of men treated with PSD502 than there were in the placebo group. There were no systemic adverse events, although a small number of men experienced a degree of numbness to the penis. This was less than 3% of the cohort.

It seems that PSD502 is going to be of great benefit to both men with rapid ejaculation and their partners: especially since the product can be used on an "on-demand" basis. It only takes five minutes before it becomes effective, and there must be many men who would like the product to be licensed as soon as possible! (Up to 75% of men ejaculate too rapidly for their liking or their partner's sexual satisfaction.) This drug certainly seems to have great promise in field of premature ejaculation treatment.

I'd also like to remind you men out there that not all sexual pleasure is down to a man's capacity to develop sufficient staying power to last a long time in bed. Pleasing a woman sexually requires a degree of skill and finesse which goes well beyond the ability to sustain a high IELT. It's worthwhile checking out this link for more information on a subset of sexual skills which are necessary for all men who (1) wish to be competent lovers and (2) have a desire to know how to please a woman in bed.

What is PSD502?

It's a new formulation of two local anesthetics, lidocaine and prilocaine, which are delivered in carefully controlled quantities by aerosol, developed by Sciele Pharma, Inc. a pharmaceutical company which focuses on developing and marketing branded prescription products to deal with cardiovascular issues, diabetes, problems in women's health, and pediatric issues. Among the portfolio are products to treat unstable angina, high cholesterol, hypertension, high triglycerides, and Type 2 diabetes. Sciele is now a wholly owned subsidiary of Shionogi, & Co., Ltd., from Osaka, Japan, whose R & D targets mostly infectious diseases, pain, and metabolic syndrome. They were responsible for developing  Crestor, the well-known anti-cholesterol drug.

We'll let you know if or when this drug gets FDA approval!


My own interpretation of comments about PE on The Male Health Centre is as follows:

Misconceptions and myths about premature ejaculation include the following:

  • Men are too sexually excited to focus on bodily sensation and so get too aroused, losing control of their bodily responses as they do so
  • A hurried first experience with intercourse induces the habit of rapid climax for life
  • Performance anxiety means men don't pay attention to their own bodily sensations (see the first point above)
  • Guilt can induce PE (presumably because any kind of emotional arousal causes increased sensitivity to exciting stimuli, both sexual and non-sexual)
  • Worrying about erectile dysfunction can cause PE (see the point immediately above)

Causes of PE

There is very little hard and fast medical evidence about the causes of PE. This is one of the reasons why it has proved so difficult to treat. It is reasoning after the event to identify a particular characteristic of men with PE and then infer that this causes PE - this applies to the suggestion that the pelvic muscles, and in particular the muscles around the erectile bodies in the penis, are hyperactive in men who experience premature ejaculation. Ejaculation involves increased activity of these muscle groups; ergo, it seems men who come too soon may have hyperactive muscles already aroused and approaching the threshold of ejaculation.

One of the experts at Male Health Center observes that he has been evaluating and treating men with sexual problems including impotence and premature ejaculation for several years, and has observed that men with premature ejaculation show increased sensitivity to vibration in the penis, at least when set alongside men who do not have the problem. He infers that PE may be caused by hypersensitivity of the penis and pelvic muscle  hyperspasticity. This idea has not been proved by research. if this is so, however, then a combination of relaxation methods and the anesthetic spray mentioned above must be a combination likely to help a man last longer in bed. In the absence of a licenses for PSD502, we recommend the program on this website and self-hypnosis.

Some antidepressants, in particular selective serotonin reuptake inhibitors (SSRIs) such as Prozac, can delay ejaculation or stop it altogether. Since serotonin in the brain is associated with a chain of events which leads to ejaculation, there may be a biochemical link here.

However, I'd fundamentally disagree with the writer's observation that the majority of cases of PE are treated pharmaceutically. My own experience has suggested that two things are key in treating PE: first, getting a man into his mature masculine power, so he feels a full awareness of his adult male sexuality, as opposed to the much more common, immature, boyish form of male sexual responsively and sexual pleasure - in other words, dealing with developmental issues around male psychology - and second, training the body to last longer before it ejaculates, which is done with a variety of methods, all of which are described on this very website.

Drug therapy

As many men who have been given SSRIs for the treatment of depression will know, delayed ejaculation is a common side-effect of antidepressant prescription medications. This has led to their use as medication for a treatment to stop or prevent premature ejaculation. However, perhaps not unexpectedly, not one of them has been approved by the FDA for use in this context: therefore, if prescribed to treat premature ejaculation they are "off label".

Attention has centered on Prozac, Zoloft, and Paxil. Early investigations demonstrated that Paxil was the most effective drug at controlling premature ejaculation, sometimes extending the interval between penetration and ejaculation from one minute to ten. However, the side effects can be troublesome, and the drug has to be taken in a calculated way about four hours before intercourse. An alternative is to take the drug daily so that spontaneous sex is still possible, but many men would balk at the idea of taking a drug to treat depression on a regular basis as a method of controlling premature ejaculation.

Even more alarmingly it has been reported that after taking the drug for between one and two weeks, men can then stop taking it on a daily basis and simply take it for hours before intercourse is required. This raises the interesting question of what biochemical changes are taking place in the brain, and what other effect these may be having on a man's long-term welfare besides preventing premature ejaculation. Intuitively it does seem strange when effective therapeutic treatments such as those described on this website are available that a man would turn to prescription medication to treat his condition, although one has to recognize the power of the medical profession at work here.

Side effects are also a problem with SSRIs: these include reduced libido, a dry mouth, anxiety, diarrhea, drowsiness and headache amongst others. If you are following research in this field you may well have heard of Dapoxetine, a drug similar to the SSRI which has been designed solely for the treatment of premature ejaculation. It reaches its maximum concentration within an hour inside the body and is removed from the body quite quickly which allows them to take it on demand rather than every day: clearly this is preferable, but again there seems to me to be a matter of principle at stake here, in that taking a prescription medication for a treatment which is psychological in origin is rather dubious. The progress of Dapoxetine has been somewhat checkered in that it has been refused a license by the FDA, although licensed by some European countries. The reasons for this are unclear although they may centre on the debate about withdrawal from SSRIs and suicide that occurred in 2005 onwards.

Counseling

As you may have gathered, our own preferred method of treating premature ejaculations through a psychological approach, which mirrors the processes used in formal counseling for marital and relationship issues. There is no doubt that premature ejaculation can offer a very significant problem in relationships, as well as having a profound effect on the man's self-esteem and sexual self-confidence. Any treatment method that approach is premature ejaculation as an isolated condition for the man himself is worthy of suspicion: the exercises on this website, for example, all involve the man's partner although the initial stages can be conducted on his own.
 

More news about developments in premature ejaculation treatment

Premature Ejaculation Treatment That Works!

If you're looking for a solution to this problem, don't hang around waiting for PSD502 (see left) to be licensed. Do something NOW!

Our treatment really works for premature ejaculation. And the best news is that it's safe, simple and quick, unlike some of the drug treatments which are being touted around at the moment - dapoxetine comes to mind. (Marketing an anti-depressant as a treatment for PE may have something to do with pharmaceutical company profits!) Using treatment you'll be able to last up to twenty minutes - more than enough to satisfy you and the most demanding female partner!

 To enjoy consistent, reliable ejaculation control, and to enjoy the greatest sexual pleasure just click on the link below and find out how to treat your premature ejaculation!

End premature ejaculation now